Antisense oligonucleotide modulation of tumor necrosis factor-.a

Details Antisense oligonucleotide modulation of tumor necrosis factor-.a Antisense oligonucleotide modulation of tumor necrosis factor-.a

1998-10-05

2000-06-27

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536245, C07H 2104, C12Q 168, C12N 1585

Patent

active

060805803

ABSTRACT:
Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-.alpha. (TNF-.alpha.). Antisense oligonucleotides targeted to nucleic acids encoding TNF-.alpha. are preferred. Methods of using these oligonucleotides for inhibition of TNF-.alpha. expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-.alpha. are provided.

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