Antisense oligonucleotide modulation of raf gene expression

Details Antisense oligonucleotide modulation of raf gene expression Antisense oligonucleotide modulation of raf gene expression

1998-08-28

2000-07-18

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

514 44, 536 245, A61K 3170, C07H 2100, C12N 506

Patent

active

06090626&

ABSTRACT:
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

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