Antisense oligonucleotide modulation of raf gene expression

Details Antisense oligonucleotide modulation of raf gene expression Antisense oligonucleotide modulation of raf gene expression

1995-06-05

1998-04-28

Elliott, George G.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

514 44, 536 245, A61K 3170, C07H 2100, C07H 2102, C12N 508

Patent

active

057443629

ABSTRACT:
Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

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