Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-06-02
2000-07-11
Schwartzman, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 435 6, 435325, 435366, C07H 2104, C12Q 168
Patent
active
060874899
ABSTRACT:
Compounds, compositions and methods are provided for modulating the expression of human thymidylate synthase. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding thymidylate synthase. Methods of using these oligonucleotides for modulation of thymidylate synthase expression and for treatment of diseases such as cancers believed to be responsive to modulation of thymidylate synthase expression are provided.
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Sartorius, C., et al., "Hybridization arrest of the cell-free translation of the malarial dihydrofolate reductase/thymidylate synthase mRNA by anti-sense oligodeoxyribonucleotides", Nucl. Acids, Res. 1991, 19, 1613-1618.
Isis Pharmaceuticals , Inc.
Schwartzman Robert A.
Wang Andrew
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