Antisense oligonucleotide modulation of B-raf gene expression

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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514 44, C07H 2100, A61K 3170

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059817313

ABSTRACT:
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

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