Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-04-14
1999-11-16
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435325, 435366, 435375, 536 231, 536 2431, 536 245, C12Q 168, C07H 2104, C12N 1585, C12P 1934
Patent
active
059855584
ABSTRACT:
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.
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Baker Brenda
Dean Nicholas M.
McKay Robert
Miraglia Loren
Degen Nancy
Isis Pharmaceuticals , Inc.
Wang Andrew
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