Antisense oligonucleotide antibiotics complementary to the macro

Details Antisense oligonucleotide antibiotics complementary to the macro Antisense oligonucleotide antibiotics complementary to the macro

1990-08-23

1994-03-15

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351723, 536 2432, C21Q 168, C12N 1500, C12N 1511

Patent

active

052945332

ABSTRACT:
A method of interrupting the expression of a macromolecular synthesis operon in bacteria comprising the step of binding an antisense oligonucleotide to a single stranded DNA or to a mRNA transcribed from the macromolecular synthesis operon. The antisense oligonucleotide can be either sequence specific to a unique intergenic sequence or a sequence specific to a bacterial homologous sequence. By interrupting the expression of the macromolecular synthesis operon bacterial infections can be treated. Specific antisense oligonucleotides are disclosed. The ability of the antisense oligonucleotide to bind the mRNA or single stranded DNA also allows the identification of the bacteria by using a unique intergenic antisense oligonucleotide to bind to the single stranded DNA or to the mRNA transcribed from the macromolecular synthesis operon. A method for competitively inhibiting the protein products of the MMS operon with oligonucleotides is also disclosed. Methods of identifying unique intergenic sequence is also disclosed.

REFERENCES:
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patent: 4851330 (1989-07-01), Kohne et al.
Erickson et al., Gene, 40:67-78 (1985).
Wang et al., Nucleic. Acids Res., 14(10):4293-4307 (1986).
Wang et al., J. Biol. Chem., 260(6):3368-3372 (1985).
Inouye et al., J. Bacteriology, 172(1):80-85 (1990).

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