Antisense oligonucleotide alkylphosphonothioates and arylphospoh

Details Antisense oligonucleotide alkylphosphonothioates and arylphospoh Antisense oligonucleotide alkylphosphonothioates and arylphospoh

1995-05-08

1999-07-27

Degen, Nancy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 231, 536 2431, 536 245, 558122, 558132, C07H 2104, C12Q 168, C07F 902

Patent

active

059292261

ABSTRACT:
The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.

REFERENCES:
patent: 4689320 (1987-08-01), Kaji
patent: 4757055 (1988-07-01), Miller et al.
patent: 5003097 (1991-03-01), Beaucage et al.
patent: 5015570 (1991-05-01), Scangos et al.
patent: 5252723 (1993-10-01), Bhatt
Richards et al. (1978) Virol. 89:395.
Stephenson and Zamecnik (1978) Proc. Natl. Acad. Sci. USA 75:285-288.
Harris et al. (1980) J. Virol. 36:659.
Campbell et al. (1984) Nature 311:350.
Stec et al. (1984) J. Am. Chem. Soc. 106:6077-6079.
Rice et al. (1985) Science 229:726.
Robertson et al. (1985) J.Virol. 54:651.
Davison and Scott (1986) J.Gen.Virol. 67:2279.
Zamecnik et al (1986) Proc. Natl. Acad. Sci. USA 83:4143-4146.
Agrawal and Goodchild (1987) Tet.Lett. 28:3539-3592.
Brill and Caruthers (1987) Tet.Lett. 28:3205-3208.
Zurita et al. (1987) Proc. Natl. Acad. Sci. USA 84:2340.
Agrawal et al. (1988) Proc. Natl. Acad. Sci. USA 85:7079-7083.
Brill and Caruthers (1988) Tet.Lett. 29:1227-1230.
Roelen et al. (1988) Nucleic Acids Res. 16:7633-7645.
Sarin et al. (1988) Proc. Natl. Acad. Sci. USA 85:7448-7451.
Agrawal et al. (1989) Proc. Natl. Acad. Sci. USA 86:7790-7794.
Stawinski et al. (1989) Nucleic Acids Res. Symposium Series No. 21:47-48.
Gao et al. (1990) Antimicrob. Agents and Chem. 34:808.
Lebadev et al. (1990) Tet.Lett. 31:855-858.
Leiter et al (1990) Proc. Natl. Acad. Sci. USA 87:3430.
Agrawal et al. (1991) Proc. Natl. Acad. Sci. USA 88:7595-7599.
Stahl and Prusiner (1991) FASEB J. 5:2799-2807.
Storey et al. (1991) Nucleic Acids Res. 19:4109-4114.
Agrawal (1992) Tibtech 10:152-158.
K. Agrawal et al Nucl. Acids. Res. 6(9) 3009-24 ('79).
J. Goodchild et al, Bioconjugate Chem. ('90) 1(3):165-186.
W. Brill et al., Nucleosides & Nucleotides 8(5&6) ('89) 1011-4.
R. Iyer et al., J. A. C. S. 112:1253-4 '90.
Roelen et al., Tetrahedron Letts. 33(17), 2357-2360 (1992).
Helinski et al., Tetrahedron Letts 32(37), 4981-4984 (1991).
Derwent Publications Ltd., Section Ch., Week 9229, May 27, 1992, see abstract (Yodogawa Pharm. Co.).
Iyer et al., J. Org. Chem. 55, 4693-4699 (1990).
Uhlmann, E., et al. Chemical Reviews, vol. 90 (4), (Jun. '90) pp. 543-584.
B.Y. Tseng et al Cancer Gene Therapy, vol. 1, No. 1, (1994) pp. 65-71.
C.A. Stein et al. Science, vol. 261 (Aug. 20, '93) pp. 1004-1012.
J. Holz et al. Med. Cell. Biol., vol. 8#2 (Feb. 1988) pp. 963-973.
M. Cooney et al. Science, vol. 241 (Jul. 22, 1988) pp. 456-459.
C. Helene et al. Biochimie, vol. 67 ('85), pp. 777-783.
D. Tidd Anticancer Res., vol. 10 ('90) pp. 1169-1182.
L. Pauling Chem. & Eng. News, vol. 24 #10 (Mar. 25, 1946) pp. 1375-1377.
P. Weszermann et al. Biomed. Biochim. Acta, vol. 48 #1 ('89) pp. 85-93.
R. Weiss Science News, vol. 139 (Feb. 16, 1991) pp. 108-109.

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