Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2001-06-13
2008-10-28
Vivlemore, Tracy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C530S300000
Reexamination Certificate
active
07442788
ABSTRACT:
An antisense molecule which acts on both directions of the inhibition and expression of a gene function and is capable of on-off switching of a gene function appropriately depending on the external factors (orientation controlling factors); and a method for reversibly controlling the expression of a gene function by using the antisense molecule. Such an antisense molecule, which has at least one sugar-base moiety consisting of sugar and a purine or pyrimidine base bonded thereto via a glucoside bond, can bind to a mRNA/gene and/or dissociate therefrom under the orientation control of the base moiety in the molecule by the orientation controlling factors.
REFERENCES:
Wada et al. Nucleic Acids Symposium Series 34, 1995, pp. 189-190.
Opalinska et al. Nature Reviews Drug Discovery, 2002, vol. 1, p. 503-514.
Takehiko Wada, et al., “Peptide Ribonucleic Acids (PRNA). 2. A Novel Strategy for Active Control of DNA Recognition through Borate Ester Formation,” Journal of the American Chemical Society, 2000, vol. 122, No. 29, pp. 6900-6910.
Takehiko Wada, et al., “Conformational and Orientational Switching of Uridine Derivatives by Borates,” Chemistry Letters 1998, pp. 1025-1026.
Takehiko Wada, et al., “Synthesis and properties of oligolysine and oligoglutamic acid derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 29, pp. 79-80.
Takehiko Wada, et al., “Synthesis and properties of polyamide derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 35, pp. 97-98.
Takehiko Wada, et al., “Synthesis and properties of oligo-ω-amino acids derivatives containing nucleosides,” Nucleic Acids Symposium Series No. 34, pp. 189-190.
Hirofumi Sato, et al., “Synthesis and conformation control of peptide ribonucleic acid containing 5′-amino-5′-deoxyribopurinenucleosides,” Nucleic Acids Symposium Series No. 44, pp. 211-212.
Isono, et al., “Polyoxin Analogs. I. Synthesis of Aminoacyl Derivatives of 5′-Amino-5′-deoxyuridine,” Chemical & Pharmaceutical Bulletin, 19(3), pp. 505-512 1971.
Chang, et al., “Analogues ofS-Adenosylhomocysteine as Potential Inhibitors of Biological Transmethylation. Synthesis of Analogues with Modifications at the 5′-Thioether Linkage,” Journal of Medicinal Chemistry, vol. 19, No. 5 pp. 684-691 1976.
Herranz, et al., “Synthesis of 5′-N-(α-amino-β-mercaptoacyl)=amino-5′-deoxynucleosides as potential antiviral compounds,” Chemical Abstracts, vol. 116, No. 1, Jan. 6, 1992.
Lee, et al., “Methionyl Adenylate Analogues as Inhibitors of Methionyl-tRNA Synthetase,” Bioorganic & Medicinal Chemistry Letters 9(10) pp. 1365-1370 1999.
Inoue Yoshihisa
Wada Takehiko
Japan Science and Technology Corporation
Knobbe Martens Olson & Bear LLP
Vivlemore Tracy
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