Antisense modulation of X-linked inhibitor of apoptosis expressi

Details Antisense modulation of X-linked inhibitor of apoptosis expressi Antisense modulation of X-linked inhibitor of apoptosis expressi

1999-09-09

2000-07-11

Brusca, John S.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 536 231, 536 241, 536 245, C07H 2104, C07H 2102, C12Q 168

Patent

active

060871733

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of X-linked inhibitor of apoptosis. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding X-linked inhibitor of apoptosis. Methods of using these compounds for modulation of X-linked inhibitor of apoptosis expression and for treatment of diseases associated with expression of X-linked inhibitor of apoptosis are provided.

REFERENCES:
Deveraux et al., IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases, Embo J., 1998, 17:2215-2223.
Deveraux et al., X-linked IAP is a direct inhibitor of cell-death proteases, Nature, 1997, 388:300-304.
Li et al., Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia, Endocrinology, 1998, 139:1321-1328.
Roy et al., The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases, Embo J., 1997, 16:6914-6925.
Stehlik et al., Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis, J. Exp. Med., 1998, 188:211-216.
Takahashi et al., A single BIR domain of XIAP sufficient for inhibiting caspases, J. Biol. Chem., 1998, 273:7787-7790.
Thompson, Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267:1456-1462.
Uren et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors, Proc. Natl. Acad. Sci. USA, 1996, 93:4974-4978.
Yamaguchi et al., XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB-1TAK1 in the BMP Signaling pathway, Embo. J., 1999, 18:179-187.

Affiliated with

Also associated with

Rating

Antisense modulation of X-linked inhibitor of apoptosis expressi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense modulation of X-linked inhibitor of apoptosis expressi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of X-linked inhibitor of apoptosis expressi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-541329