Antisense modulation of TRADD expression

Details Antisense modulation of TRADD expression Antisense modulation of TRADD expression

1998-08-28

2000-06-20

Brusca, John S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 241, 536 245, C07H 2104, C07H 2102

Patent

active

060776722

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of TRADD. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TRADD. Methods of using these compounds for modulation of TRADD expression and for treatment of diseases associated with expression of TRADD are provided.

REFERENCES:
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Darnay et al., Early events in TNF signaling: a story of associations and dissociations, J. Leukoc. Biol., 1997, 61:559-566.
Tewari et al., Recent advances in tumor necrosis factor and CD40 signaling, Curr. Opin. Genet. Dev., 1996, 6:39-44.
Tracey et al., Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Ann. Rev. Med., 1994, 45:491-503.

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