Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-09-29
2000-06-20
Brusca, John S.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435377, 435455, 536 231, 536 241, 536 245, C07H 2104, C07H 2102, C12Q 168
Patent
active
060777095
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
REFERENCES:
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Agrawal, S. "Antisense oligonucleotides: Towards Clinical Trials" TIBTECH vol. 14:376-387, Oct. 1996.
Milner et al. "Selecting Effective Antisense Reagents on Combinitorial Arrays" Nature Biotechnology vol. 14: 537-541, Jun. 1997.
Adida et al., Anti-apoptosis gene, survivin, and prognosis of neuroblastoma, Lancet, 1998, 351:882-883.
Ambrosini et al., A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma, Nat. Med., 1997, 3:917-921.
Ambrosini et al., Induction of Apoptosis and Inhibition of Cell Proliferation by Survivin Gene Targeting, J. Bio. Chem., 1998, 273:11177-11182.
Cohen, Caspases: the executioners of apoptosis, Biochemistry Journal, 1997, 326:1-6.
Lu et al., Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas, Cancer Res., 1998, 58:1808-1812.
Ackermann Elizabeth J.
Bennett C. Frank
Cowsert Lex M.
Swayze Eric E.
Brusca John S.
Isis Pharmaceuticals , Inc.
McGarry Sean
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