Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-04-05
2000-12-26
Brusca, John S.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435377, 435455, 536 231, 536 241, 536 245, C07H 2104, C07H 2102, C12Q 168
Patent
active
061657883
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
REFERENCES:
Branch, A. "A Good Antisense Molecule is Hard to Find" TIBS vol. 23:45-50, Feb. 1998.
Agrawal, S. "Antisense oligonucleotides: Towards Clinical Trials" TIBTECH vol. 14:376-387, Oct. 1996.
Milner et al. "Selecting Effective Antisense Reagents on Combinitorial Arrays" Nature Biotechnology vol. 14: 537-541, Jun. 1997.
Li F., et al., "Control of apoptosis and mitotic spindle checkpoint by survivin", Nature, 1998, 386: 580-584.
Ackermann Elizabeth J.
Bennett C. Frank
Cowsert Lex M.
Swayze Eric E.
Brusca John S.
ISIS Pharmaceuticals Inc.
Mc Garry Sean
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