Antisense modulation of stat3 expression

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 911, 435325, 536 231, 536 243, 536 245, C12Q 168, C07H 2104, C12N 1585

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061596949

ABSTRACT:
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 are provided.

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Grandis et al., "Requirement of Stat3 but not Stat1 Activation for Epidermal Growth Factor Receptor-mediated Cell Growth in Vitro", J. Clin. Invest., 1998, 102, 1385-1392.

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