Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-03-29
2000-08-22
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435455, 536 245, 536 241, 536 231, 536 251, C07H 2104, C12N 1509, C12Q 168
Patent
active
061070920
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the function or amount of SRA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to SRA or nucleic acids encoding SRA. Methods of using these compounds for modulation of SRA levels and for treatment of diseases associated with SRA are provided.
REFERENCES:
Branch, A., "A Good Antisense Molecule is Hard to Find" TIBS vol. 23:45-50. Feb. 1928.
Agarwal, S., "Antisense Oligonucleotides: Towards Clinical Trials" TIBTECH vol. 14:376-387, Oct. 1996.
Glass et al., Nuclear receptor coactivators, Curr. Opin. Cell. Biol., 1997, 9:222-232.
Onate et al., Sequence and characterization of a coactivator for the steroid hormone receptor superfamily, Science, 1995, 270:1354-1357.
Bennett C. Frank
Cowsert Lex M.
O'Malley Bert W.
Baylor College of Medicine
Elliott George C.
Isis Pharmaceuticals , Inc.
Licata Jane Massey
McGarry Sean
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