Antisense modulation of Ship-2 expression

Details Antisense modulation of Ship-2 expression Antisense modulation of Ship-2 expression

1999-06-25

2000-02-15

Elliot, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500

Patent

active

060251980

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Ship-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Ship-2. Methods of using these compounds for modulation of Ship-2 expression and for treatment of diseases associated with expression of Ship-2 are provided.

REFERENCES:
Habib et al., Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein, J. Biol. Chem., 1998, 273:18605-18609.
Pesesse et al., Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP, Biochem. Biophys. Res. Commun., 1997, 239:697-700.
Pesesse et al., The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3, 4, 5-trisphosphate and inositol 1, 3, 4, 5-tetrakisphosphate 5-phosphatase activity [In Process Citation], FEBS Lett., 1998, 437:301-303.

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