Antisense modulation of Sentrin expression

Details Antisense modulation of Sentrin expression Antisense modulation of Sentrin expression

1998-12-17

1999-11-16

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

059856645

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Sentrin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Sentrin. Methods of using these compounds for modulation of Sentrin expression and for treatment of diseases associated with expression of Sentrin are provided.

REFERENCES:
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Gong et al., Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9, J. Biol. Chem., 1997, 272:28198-28201.
Mahajan et al., A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2, Cell, 1997, 88:97-107.
Okura et al., Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin, J. Immunol., 1996, 157:4277-4281.
Schwarz et al., The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme, Proc. Natl. Acad. Sci. U S A, 1998, 95:560-564.
Shen et al., UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins, Genomics, 1996, 36:271-279.
Sternsdorf et al., Evidence for covalent modification of the nuclear dot-assoicated proteins PML and Sp100 by PIC1/SUMO-1, J. Cell Biol., 1997, 139:1621-1634.

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