Antisense modulation of RIP-1 expression

Details Antisense modulation of RIP-1 expression Antisense modulation of RIP-1 expression

1998-09-25

2000-02-01

Brusca, John S.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 536 231, 536 241, 536 245, C07H 2104, C07H 2102, C12N 1511

Patent

active

060201983

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of RIP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RIP-1. Methods of using these compounds for modulation of RIP-1 expression and for treatment of diseases associated with expression of RIP-1 are provided.

REFERENCES:
patent: 5639598 (1997-06-01), Weiner et al.
patent: 5674734 (1997-10-01), Leder et al.
Feig et al., Evidence for a Ras/Ral signaling cascade, Trends Biochem. Sci., 1996, 21:438-441.
Matsubara et al., The post-translational modifications of Ral and Racl are important for the action of Ral-binding protein 1, a putative effector protein of Ral, FEBS Lett., 1997, 410:169-174.

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