Antisense modulation of RhoG expression

Details Antisense modulation of RhoG expression Antisense modulation of RhoG expression

1998-09-25

1999-10-12

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435325, 435366, 435375, 536 231, 536 2431, 536 245, C12Q 168, C12N 1585, C12P 1934, C07H 2104

Patent

active

059653701

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of RhoG. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RhoG. Methods of using these compounds for modulation of RhoG expression and for treatment of diseases associated with expression of RhoG are provided.

REFERENCES:
Narumiya, Rho gene products, botulinum C3 exoenzyme and cell adhesion, Cell Signal, 1993, 5:9-19.
Roux, The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells, Curr. Biol., 1997, 7:629-637.
Vincent, Growth-regulated expression of rhoG, a new member of the ras homolog gene family, Mol. Cell. Biol., 1992, 12:3138-3148.

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