Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-07-21
2000-02-01
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500
Patent
active
060201991
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of PTEN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTEN. Methods of using these compounds for modulation of PTEN expression and for treatment of diseases associated with expression of PTEN are provided.
REFERENCES:
Tamura et al., Science 280: 1614-1617, Jun. 1998.
Devlin et al., Proc. Am. Assoc. Cancer Res. Ann Mtg., 40p438, Mar. 1999.
Arch et al., Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease, Am. J. Med. Genet., 1997, 71:489-493.
Di Cristofano et al., Pten is essential for embryonic development and tumour suppression, Nat. Genet., 1998, 19:348-355.
Li et al., TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta, Cancer Res., 1997, 57:2124-2129.
Li et al., PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 1997, 275:1943-1947.
Liaw et al., Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome, Nat. Genet., 1997, 16:64-67.
Maehama et al., The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate, J. Biol. Chem., 1998, 273:13375-13378.
Marsh et al., Germline mutations in PTEN are present in Bannayan-Zonana syndrome, Nat. Genet., 1997, 16:333-334.
Nelen et al., Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease, Hum. Mol. Genet., 1997 6:1383-1387.
Stambolic et al., Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN, Cell, 1998, 95:29-39.
Steck et al., Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers, Nat. Genet., 1997, 15:356-362.
Stephens et al., Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B, Science, 1998, 279:710-714.
Tamura et al., Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN, Science, 1998, 280:1614-1617.
Teng et al., MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines, Cancer Res., 1997, 57:5221-5225.
Tsou et al., The genetic basic of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1, Hum. Genet., 1998, 102:467-473.
Cowsert Lex M.
Monia Brett P.
Elliott George C.
Isis Pharmaceuticals , Inc.
Schmidt Melissa
LandOfFree
Antisense modulation of PTEN expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense modulation of PTEN expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of PTEN expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-936777