Antisense modulation of PI3 kinase p55 gamma expression

Details Antisense modulation of PI3 kinase p55 gamma expression Antisense modulation of PI3 kinase p55 gamma expression

1999-11-03

2000-12-26

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435325, 435455, 435366, 536 231, 536 245, 536 253, C12Q 168, C12P 1934, C12N 1500, C07H 2104

Patent

active

061657905

ABSTRACT:
Antisense compounds, compositions and methods are provided for inhibiting the expression of PI3 kinase p55 gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p55 gamma. Methods of using these compounds for inhibition of PI3 kinase p55 gamma expression and for treatment of diseases associated with expression of PI3 kinase p55 gamma are provided.

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A. Branch. 1998 Trends in Bioch. Sci. (TIBS) vol. 23, pp. 45-50.
S. Crooke 1998 Antisense Research & Application. chapt 1, pp. 1-50. Springer-Publisher.
Dey et al., Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor [published erratum appears in Gene May 28, 1998;212(1):155], Gene, 1998, 209:175-183.
Fry, Structure, regulation and function of phosphoinositide 3-kinases, Biochim. Biophys. Acta., 1994, 1226:237-268.
Shin et al., Multiple isoforms of the regulatory subunit for phosphatidylinositol 3-kinase (PI3-kinase) are expressed in neurons in the rat brain, Biochem. Biophys. Res. Commun., 1998, 246:313-319.

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