Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-07-19
2000-04-04
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500
Patent
active
060460490
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of PI3 kinase p110 delta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p110 delta. Methods of using these compounds for modulation of PI3 kinase p110 delta expression and for treatment of diseases associated with expression of PI3 kinase p110 delta are provided.
REFERENCES:
patent: 5741689 (1998-04-01), Dhand et al.
patent: 5858753 (1999-01-01), Chantry et al.
patent: 5882910 (1999-03-01), Chantry et al.
Deora et al., A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress, J. Biol. Chem., 1998, 273:29923-29928.
Fry, Structure, regulation and function of phosphoinositide 3-kinases, Biochim. Biophys. Acta., 1994, 1226:237-268.
Hu et al., Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3- kinase and identification of its binding site on p85, Mol. Cell. Biol., 1993, 13:7677-7688.
Molz et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain, J. Biol. Chem., 1996, 271:13892-13899.
Schu et al., Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting, Science, 1993, 260:88-91.
Stirdivant et al., Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase, Bioorg. Med. Chem., 1997, 5:65-74.
Stoyanov et al., Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase, Science, 1995, 269:690-693.
Ui et al., Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase, Trends Biochem. Sci., 1995, 20:303-307.
Vanhaesebroeck et al., P110delta, a novel phosphoinositide 3-kinase in leukocytes, Proc. Natl. Acad. Sci. U. S. A., 1997, 94:4330-4335.
Vlahos et al., A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), J. Biol. Chem., 1994, 269:5241-5248.
Woscholski et al., A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase, FEBS Lett., 1994, 342:109-114 .
Cowsert Lex M.
Monia Brett P.
Elliott George C.
Isis Pharmaceuticals , Inc.
Schmidt Melissa
LandOfFree
Antisense modulation of PI3 kinase p110 delta expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense modulation of PI3 kinase p110 delta expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of PI3 kinase p110 delta expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-364308