Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-03-19
1999-09-21
LeGuyander, John L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 435 911, 435375, 536 231, 536 2431, 536 245, A61K 4800, C07H 2104, C12Q 168
Patent
active
059554436
ABSTRACT:
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a platelet endothelial cell adhesion molecule-1 (PECAM-1; also known as CD31 antigen or endoCAM) protein are provided.
REFERENCES:
patent: 5264554 (1993-11-01), Newman
patent: 5668012 (1997-09-01), Newman et al.
Berman et al., "Roles of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1, CD31) in Natural Killer Cell Transendothelial Migration and .beta..sub.2 Integrin Activation .sup.1 ", J. Immunol., 1996, 1516, 1515.
Bogen et al., "Monoclonal Antibody to Murine (PECAM-1 (CD31) Blocks Acute Inflammation In Vivo", J. Exp. Med., 1994, 179, 1059.
Lastres et al., "Functional Regulation of Platelet/Endothelial Cell Adhesion Molecule-1 by TGF-.beta.1 in Promonocytic U-937 Cells.sup.1 ", J. Immunol., 1994, 153, 4206.
Liao et al., "Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo", J. Exp. Med., 1997, 185, 1349.
Murohara et al., "Blockade of Platelet Endothelial Cell Adhesion Molecule-1 Protects Against Myocardial Ischemia and Reperfusion Injury in Cats .sup.1 ", J. Immuol., 1996, 156, 3550.
Tang et al., "Indentification of PECAM-1 in Solid Tumor Cells and Its Potential Involvement in Tumor Cell Adhesion to Endothelium", J. Biol. Chem., 1993, 268, 22883.
Vaporciyan et al., "Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo", Science, 1993, 262, 1580.
Newman, "Perspective Series: Cell Adhesion in Vascular Biology", J. Clin. Invest., 1997, 99, 3.
DeLisser et al., "Molecular and functional aspects of PECAM-1/CD31", Immunol. Today, 1994, 15, 490.
Newman et al., "PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily", Science, 1990, 247, 1219.
Xie et al., "Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1", Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 5569.
Albelda et al., "Adhesion molecules and inflammatory injury", J. Cell Biol., 1991, 114, 1059.
Branch. Tibs. 23, 45-50 (Feb. 1998).
Skorski et al. Blood. 88 (3), 1005-1012 (Aug. 1, 1996).
Milligan et al. J. Medicinal Chem. 36 (14), 1923-1937 (Jul. 9, 1993).
Golden. Time Magazine. May 18, 1998. pp. 38-50.
Milner et al. Nature Biotechnology. 15, 537-541 (Jun. 1997).
Bennett C. Frank
Condon Thomas P.
Flournoy Shin Cheng
Zhang Hong
Isis Pharmaceuticals , Inc.
LeGuyander John L.
Shibuya Mark L.
LandOfFree
Antisense modulation of PECAM-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense modulation of PECAM-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of PECAM-1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-80335