Antisense modulation of P38 mitogen activated protein kinase exp

Details Antisense modulation of P38 mitogen activated protein kinase exp Antisense modulation of P38 mitogen activated protein kinase exp

1999-04-06

2000-10-31

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

536 231, 536 243, 536 2431, 536 2433, 536 245, 435 6, 435 911, 435325, C07H 2104, C07H 2102, C12N 500, C12Q 168

Patent

active

061401242

ABSTRACT:
Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.

REFERENCES:
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patent: 5856462 (1999-01-01), Agrawal
Aoshiba et al., "Role of p38-Mitogen-Activated Protein Kinase in Spontaneous Apoptosis of Human Neutrophils", J. Immunol., 1999, 162, 1692-1700.
Cohen et al., "The Critical Role of p38 MAP Kinase in T Cell HIV-1 Replication", Mol. Med., 1997, 3, 339-346.
Nagata et al., "Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation", Blood, 1998, 6, 1859-1869.
Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
Trisha Gura, Antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995.
Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jul. 1998.

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