Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1999-11-03
2000-12-26
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 6, 435 911, 435455, 435325, 435366, 536 231, 536 245, 536 253, C12Q 168, C12P 1934, C07H 2102, C07H 2104, C07H 2100
Patent
active
061657867
ABSTRACT:
Antisense compounds, compositions and methods are provided for inhibiting the expression of Nucleolin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Nucleolin. Methods of using these compounds for modulation of Nucleolin expression and for treatment of diseases associated with expression of Nucleolin are provided.
REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
Milner, N. et al. 1997 Nature: Biotech. vol. 15, pp. 537-541.
James, W. 1991. Antiviral Chem & Chenotner vol. 2 (4), pp. 191-214.
Branch, A. 1998 Trends in Biochem Sci (TIBS) vol. 23, pp. 45-50.
Crooke, St. 1998/ Antisense Res & Applica. Chapter 1: pp. 1-50. (Springer-Publ.).
Bates, P J et al. 1999 J. Biol Chem. vol. 274 (37) pp. 26,369-26,377.
Belenguer et al., Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase, Mol. Cell. Biol., 1990, 10:3607-3618.
Bell et al., Specificity of antinuclear antibodies in scleroderma-like chronic graft- versus-host disease: clinical correlation and histocompatibility locus antigen association, Br. J. Dermatol., 1996, 134:848-854.
Bugler et al., RNA binding fragments from nucleolin contain the ribonucleoprotein consensus sequence, J. Biol. Chem., 1987, 262:10922-10925.
Chen et al., Increased stability of nucleolin in proliferating cells by inhibition of its self-cleaving activity, J. Biol. Chem., 1991, 266:7754-7758.
Creancier et al., Determination of the functional domains involved in nucleolar targeting of nucleolin, Mol. Biol. Cell., 1993, 4:1239-1250.
Csermely et al., Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei, J. Biol. Chem., 1993, 268:9747-9752.
Dickinson et al., Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential, Mol. Cell. Biol., 1995, 15:456-465.
Erard et al., A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1, Eur. J. Biochem., 1988, 175:525-530.
Fang et al., The self-cleaving activity of nucleolin determines its molecular dynamics in relation to cell proliferation, Exp. Cell. Res., 1993, 208:48-53.
Ghisolfi et al., Nucleolin--pre-rRNA interactions and preribosome assembly, Mol. Biol. Rep., 1990, 14:113-114.
Ghisolfi-Nieto et al., Nucleolin is a sequence-specific RNA-binding protein: characterization of targets on pre-ribosomal RNA, J. Mol. Biol., 1996, 260:34-53.
Lapeyre et al., Nucleolin, the major nucleolar protein of growing eukaryotic cells: an unusual protein structure revealed by the nucleotide sequence, Proc. Natl. Acad. Sci. U. S. A., 1987, 84:1472-1476.
Minota et al., Reactivity of autoantibodies and DNA/anti-DNA complexes with a novel 110-kilodalton phosphoprotein in systemic lupus erythematosus and other diseases, J. Immunol., 1990, 144:1263-1269.
Minota et al., Autoantibodies to nucleolin in systemic lupus erythematosus and other diseases, J. Immunol., 1991, 146:2249-2252.
Pasternack et al., Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro, J. Biol. Chem., 1991, 266:14703-14708.
Roussel et al., Nucleolin is an Ag-NOR protein; this property is determined by its amino-terminal domain independently of its phosphorylation state, Exp. Cell. Res., 1992, 203:259-269.
Sapp et al., Characterization of a 48-kDa nucleic-acid-binding fragment of nucleolin, Eur. J. Biochem., 1989, 179:541-548.
Schmidt-Zachmann et al., Nuclear export of proteins: the role of nuclear retention, Cell, 1993, 74:493-504.
Schmidt-Zachmann et al., Protein localization to the nucleolus: a search for targeting domains in nucleolin, J. Cell Sci., 1993, 105:799-806.
Schneider et al., Nucleolin (C23), a physiological substrate for casein kinase II, Biochem. Biophys. Res. Commun., 1988, 156:1390-1397.
Sipos et al., Nucleolin promotes secondary structure in ribosomal RNA, Biochem. Biophys. Res. Commun., 1991, 177:673-678.
Srivastava et al., Cloning and sequencing of the human nucleolin cDNA, FEBS Lett, 1989, 250:99-105.
Srivastava et al., Genomic organization and chromosomal localization of the human nucleolin gene, J. Biol. Chem., 1990, 265:14922-14931.
Tuteja et al., Nucleolin: a multifunctional major nucleolar phosphoprotein [In Process Citation], Crit. Rev. Biochem. Mol. Biol., 1998, 33:407-436.
Zhou et al., Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells, J. Biol. Chem., 1997, 272:31130-31137.
Bennett C. Frank
Cowsert Lex M.
Elliott George C.
ISIS Pharmaceuticals Inc.
Zara Jane
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