Antisense modulation of microtubule-associated protein 4 express

Details Antisense modulation of microtubule-associated protein 4 express Antisense modulation of microtubule-associated protein 4 express

1999-04-08

1999-12-07

Elliot, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 6, 435325, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

059981482

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of microtubule-associated protein 4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding microtubule-associated protein 4. Methods of using these compounds for modulation of microtubule-associated protein 4 expression and for treatment of diseases associated with expression of microtubule-associated protein 4 are provided.

REFERENCES:
Bulinski et al., Overexpression of MAP4 inhibits organelle motility and trafficking in vivo, J. Cell Sci., 1997, 110:3055-3064.
Code et al., Mouse microtubule-associated protein 4 (MAP4) transcript diversity generated by alternative polyadenylation, Gene, 1992, 122:367-370.
Illenberger et al., Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics, J. Biol. Chem., 1996, 271:10834-10843.
Maccioni et al., Role of microtubule-associated proteins in the control of microtubule assembly, Physiol. Rev., 1995, 75:835-864.
Mangan et al., A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis, Development, 1996, 122:771-781.
Nguyen et al., Overexpression of Full-or partial-length MAP4 stabilizes microtubules and alters cell growth, J. Cell Sci., 1997, 110:281-294.
Olmsted, Microtubule-associated proteins, Annu. Rev. Cell Biol., 1986, 2:421-457.
Ookata et al., MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4, Biochemistry, 1997, 36:15873-15883.
Parysek et al., MAP 4: a microtubule-associated protein specific for a subset of tissue microtubules,J. Cell Biol., 1984, 99:2287-2296.
Wang et al., Removal of MAP4 from microtubules in vivo produces no observable phenotype at the cellular level, J. Cell Biol., 1996, 132:345-357.
West et al., A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences, J. Biol. Chem., 1991, 266:21886-21896.
Zhang et al., The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells, Oncogene, 1998, 16:1617-1624.

Affiliated with

Also associated with

Rating

Antisense modulation of microtubule-associated protein 4 express does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense modulation of microtubule-associated protein 4 express, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of microtubule-associated protein 4 express will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-822442