Antisense modulation of MDMX expression

Details Antisense modulation of MDMX expression Antisense modulation of MDMX expression

1999-04-09

2000-04-04

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 232, 536 243, 536 2433, 435 6, 435 911, 435325, 435375, C07H 2104, C07H 2102, C12Q 168, C12N 1585, C12N 1586

Patent

active

060463201

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of MDMX. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MDMX. Methods of using these compounds for modulation of MDMX expression and for treatment of diseases associated with expression of MDMX are provided.

REFERENCES:
Momand et al., Mdm-2: "big brother" of p53, J. Cell. Biochem., 1997, 64:343-352.
Shvarts et al., Isolation and identification of the human homolog of a new p53-binding protein, Mdmx, Genomics, 1997, 43:34-42.
Shvarts et al., MDMX: a novel p53-binding protein with some functional properties of MDM2, Embo J., 1996, 15:5349-5357.

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