Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-03-20
1999-12-14
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435371, 536 231, 536 2431, 536 2433, 536 245, C12N 1585, C12N 2104, C12N 1511, C12Q 168
Patent
active
060016515
ABSTRACT:
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a lymphocyte function associated antigen 3 (LFA-3; also known as CD58) protein are provided.
REFERENCES:
patent: 4956281 (1990-09-01), Wallner et al.
patent: 5185441 (1993-02-01), Wallner et al.
patent: 5354665 (1994-10-01), Wallner et al.
patent: 5547853 (1996-08-01), Wallner et al.
patent: 5556943 (1996-09-01), Yamashita et al.
Milligan Et Al. J. Medicinal Chemistry. vol. 36, 1923-1937 (Jul. 09, 1993).
Mitsuhashi. J. Gastroenterol. vol. 32, 282-287 (1997).
Gewirtz Et Al. PNAS. vol. 93, 3161-3163 (Apr. 1996).
Rojanasakul. Adv. Drug Delivery Reviews. vol. 18, 115-131 (Jan. 1996).
Branch. TIBS. vol. 23, 45-50 (Feb. 1998).
Albelda, et al., "Adhesion molecules and inflammatory injury", FASEB J., 1994, 8, 504.
Seed, "An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2", Nature, 1987, 329, 840.
Sanchez-Madrid, et al., "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1. LFA-2, and LFA-3", Proc. Natl. Acad. Sci. U.S.A., 1982, 79, 7489.
Sultan, et al., "Blockade of CD-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras", Nature Biotech., 1997, 15, 759.
Makgoba, et al., "The CD2-LFA-3 and LFA-1 1-ICAM pathways: relevance to T-cell recognition", Immunology Today, 1989, 10, 417.
Bierer, et al., "T cell adhesion molecules", FASEB J., 1988, 2, 2584.
Dustin, et al., "Role of Lymphocyte Adhesion Receptors in Transient Interactions And Cell Locomotion", Annu. Rev. Immunol., 1991, 9, 27.
Wallner, et al. "Primary Structure of Lymphocyte Function-Associated Antigen 3 (LFA-3) The Ligand of the T Lymphocyte CD2 Glycoprotein", J. Exp. Med., 1987, 166, 923.
Bennett C. Frank
Condon Thomas P.
Flournoy Shin Cheng
Ma Weillie
Pober Jordan S.
Isis Pharmaceuticals , Inc.
LeGuyader John L.
Shibuya Mark L.
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