Antisense modulation of interleukin-5 signal transduction

Details Antisense modulation of interleukin-5 signal transduction Antisense modulation of interleukin-5 signal transduction

1999-03-26

2000-10-24

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

06136603&

ABSTRACT:
Compositions and methods are provided for antisense modulation of interleukin-5 signal transduction. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding interleukin-5 and interleukin-5 receptor.alpha. are preferred. Methods of using these compounds for modulation of interleukin-5 signal transduction and for treatment of diseases associated with interleukin-5 signal transduction are also provided.

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Weltman and Karim, "Interleukin-5: A Proeosinophil Cytokine Mediator of Inflammation in Asthma and a Target for Antisense Therapy", Allergy Asthma Proc., 1998, 19: 257-261.

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