Antisense modulation of hnRNP A1 expression

Details Antisense modulation of hnRNP A1 expression Antisense modulation of hnRNP A1 expression

1999-10-27

2000-12-26

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C07H 2104, A61K 4800, C12N 1500, C12N 1585

Patent

active

061657891

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of hnRNP A1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hnRNP A1. Methods of using these compounds for modulation of hnRNP A1 expression and for treatment of diseases associated with expression of hnRNP A1 are provided.

REFERENCES:
Branch, TIBS 23, pp. 45-50, Feb. 1998.
Flanagan et al., Nature Biotech. 17:48-52, Jan. 1999.
Ben-David et al., Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth, Mol. Cell. Biol., 1992, 12:4449-4455.
Black et al., Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements, J. Virol., 1995, 69:6852-6858.
Brockstedt et al., Identification of apoptosis--associated proteins in a human Burkitt lymphona cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3 [published erratum appears in J Biol Chem 1998 Dec. 11;273 (50) :33884], J. Biol. Chem., 1998, 273:28057-28064.
Casas-Finet et al., Mammalian heterogeneous ribonucleoprotein A1 and its constituent domains. Nucleic acid interaction, structural stability and self- association, J. Mol. Biol., 1993, 229:873-889.
Cobianchi et al., Human hnRNP protein A1: a model polypeptide for a structural and genetic investigation of a broad family of RNA binding proteins, Genetica, 1994, 94:101-114.
Kumar et al., Mammalian heterogeneous nuclear ribonucleoprotein A1. Nucleic acid binding properties of the COOH-terminal domain, J. Biol. Chem., 1990, 265:17094-17100.
LaBranche et al., Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase [see comments], Nat. Genet., 1998, 19:199-202.
Mayeda et al., Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF, Mol. Cell. Biol., 1993, 13:2993-3001.
Mayeda et al., Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2, Cell, 1992, 68:365-375.
Munroe et al., Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNAuRNA annealing, Proc. Natl. Acad. Sci. U.S.A., 1992, 89:895-899.
Nadler et al., Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: evidence for multiple RNA binding domains and salt-dependent binding mode transitions, Biochemistry, 1991, 30:2968-2976.

Affiliated with

Also associated with

Rating

Antisense modulation of hnRNP A1 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense modulation of hnRNP A1 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of hnRNP A1 expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-993612