Antisense modulation of FADD expression

Details Antisense modulation of FADD expression Antisense modulation of FADD expression

1999-07-19

2000-01-18

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435 913, 536 241, 536 231, 536 245, C07H 2104, C12Q 168, C12N 1500

Patent

active

060157127

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of FADD. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding FADD. Methods of using these compounds for modulation of FADD expression and for treatment of diseases associated with expression of FADD are provided.

REFERENCES:
Micheau et al. Fas Ligand-Independent, FADD-Mediated Activation of the Fas Death Pathway by Anticancer Drugs. The Journal of Biological Chemistry vol. 274(12):7987-7992, Mar. 19, 1999.
Chinnaiyan et al., FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell, 1995, 81:505-512.
Chinnaiyan et al., FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis, J. Biol. Chem., 1996, 271:4961-4965.
Choi et al., Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway, J. Biol. Chem., 1998, 273:20185-20188.
Herr et al., Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis, Embo J., 1997, 16:6200-6208.
Kondo et al., FADD gene therapy for malignant gliomas in vitro and in vivo [In Process Citation], Hum. Gene Ther., 1998, 9:1599-1608.
Newton et al., A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes, Embo J., 1998, 17:706-718.
Schwandner et al., TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase, J. Biol. Chem., 1998, 273:5916-5922.
Thompson, Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267:1456-1462.
Walsh et al., A role for FADD in T cell activation and development, Immunity, 1998, 8:439-449.
Yeh et al., FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis, Science, 1998, 279:1954-1958.
Zhang et al., Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1, Nature, 1998, 392:296-300.

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