Antisense modulation of damage-specific DNA binding protein...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S006120, C435S325000, C435S375000, C536S023100, C536S024500

Reexamination Certificate

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06855700

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Damage-specific DNA binding protein 1, p127. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Damage-specific DNA binding protein 1, p127. Methods of using these compounds for modulation of Damage-specific DNA binding protein 1, p127 expression and for treatment of diseases associated with expression of Damage-specific DNA binding protein 1, p127 are provided.

REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
Krishnamoorthy et al., Biochemistry 1997. 36(4)960-969.*
Branch, A. D., (1998). Trends Biochem Sci. Feb. 1998;23(2):45-50.*
Gewirtz et al., Proc. Natl. Acad. Sci v 93, pp. 3161-3163.*
Taylor et al., Drug Discov Today. Dec. 1999;4(12):562-567.*
Milner et al., Nature Biotechnology. 1997 v. 15 537-540.*
Crooke et al., ed. (1998) Handbook of experimental pharmacology. v. 31: Ch. 1Antisense Research and Application 1-50. Springer-Verlag, Berlin.*
NCBI Sequence Viewer. Sequence NM_001923.*
NCBI Sequence Viewer, Sequence U18299.*
Butel et al.,Viral co-factors in liver cancer: lessons from hepatitis B virus, Princess Takamatsu Symp., 1995, 25:185-198.
Dualan et al.,Chromosomal localization and cDNA cloning of the genes(DDB1 and DDB2)for the p127 and p48 subunits of a human damage-specific DNA binding protein, Genomics, 1995, 29:62-69.
Dyson,The regulation of E2F by pRB-family proteins, Genes&Development, 1998, 12:2245-2262.
Hayes et al.,DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1, Mol. Cell. Biol., 1998, 18:240-249.
Hwang et al.,Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair, Proc. Natl. Acad. Sci. U. S. A., 1999, 96:424-428.
Hwang et al.,Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells, Mutat. Res., 1996, 362:105-117.
Itoh et al.,A newly identified patient with clinical xeroderma pigmentosum phenotype has a non-sense mutation in the DDB2 gene and incomplete repair in(6-4)photoproducts, J. Invest. Dermatol., 1999, 113:251-257.
Kannan et al.,Profile of gene expression regulated by induced p53: connection to the TGF-beta family, FEBS Lett., 2000, 470:77-82.
Keeney et al.,Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E, J. Biol. Chem., 1993, 268:21293-21300.
Keeney et al.,Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein, Proc. Natl. Acad. Sci. U. S. A., 1994, 91:4053-4056.
Lavia et al.,E2F target genes and cell-cycle checkpoint control[In Process Citation], BioEssays, 1999, 21:221-230.
Lin et al.,The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein, Virology, 1998, 249:189-200.
Nichols et al.,Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation, J. Biol. Chem., 2000, 275:21422-21428.
Shiyanov et al.,The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription, Mol. Cell. Biol., 1999, 19:4935-4943.
Shiyanov et al.,Cullin 4A associates with the UV-damaged DNA-binding protein DDB, J.Biol. Chem., 1999, 274:35309-35312.
Sladek,E2F transcription factor action, regulation and possible role in human cancer, Cell. Prolif., 1997, 30:97-105.
Watanabe et al.,A 127-kDa protein(UV-DDB)binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein, J. Neurochem., 1999, 72:549-556.
Yamasaki,Growth regulation by the E2F and DP transcription factor families, Results Probl. Cell. Differ., 1998, 22:199-227.

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