Antisense modulation of cREL expression

Details Antisense modulation of cREL expression Antisense modulation of cREL expression

1998-09-18

1999-12-14

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435369, 435371, 536 231, 536 2431, 536 245, C12N 1585, C12N 1511, C12Q 168, C07H 2104

Patent

active

060016523

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of cREL. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cREL. Methods of using these compounds for modulation of cREL expression and for treatment of diseases associated with expression of cREL are provided.

REFERENCES:
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Crooke, S.T., Chapter 1, pp. 1-50 in Antisense Research and Application (ed. Stanley T. Crooke) Springer-Verlag, New York, Jul. 1999.
Baeuerle et al., Function and activation of NF-kappa B in the immune system, Annu. Rev. Immunol., 1994, 12:141-179.
Carrasco et al., Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein, J. Exp. Med., 1998, 187:973-984.
Ghosh et al., NF-kappa B and rel proteins: evolutionarily conserved mediators of immune responses, Annu. Rev. Immunol., 1998, 16:225-260.
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Himes et al., High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters, Immunity, 1996, 5:479-489.

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