Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-31
2005-05-31
McGarry, Sean (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S006120, C536S023100, C536S024100
Reexamination Certificate
active
06900306
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of CoREST. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CoREST. Methods of using these compounds for modulation of CoREST expression and for treatment of diseases associated with expression of CoREST are provided.
REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5998148 (1999-12-01), Bennett et al.
Weintraub H., Scientific American, pp. 40-46, 1990.*
Jen et al., Stem Cells, vol. 18:307-319, 2000.*
Agrawal et al., TIBTECH vol. 14:376-387, 1996.*
Branch A., TIBS, vol. 23:45-50, 1998.*
Aasland et al.,The SANT domain: a putative DNA—binding domain in the SWI—SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB, Trends Biochem. Sci., 1996, 21:87-88.
Andres et al.,CoREST: a functional corepressor required for regulation of neural-specific gene expression, Proc. Natl. Acad. Sci. U. S. A., 1999, 96:9873-9878.
Ayer,Histone deacetylases: transcriptional repression with SINers and NuRDs, Trends in Cell Biology, 1999, 9:193-198.
DePinho,Transcriptional repression. The cancer-chromatin connection, Nature, 1998, 391:533, 535-536.
Grimes et al.,The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex, J. Biol. Chem., 2000, 275:9461-9467.
Humphrey et al.,Stable histone deactylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1, J. Biol. Chem., 2001, 276:6817-6824.
Kouzarides,Histone acetylases and deacetylases in cell proliferation, Current Opinion in Genetics&Development, 1999, 9:40-48.
You et al.,CoREST is an integral component of the CoREST—human histone deacetylase complex, Proc. Natl. Acad. Sci. U. S. A., 2001, 98:1454-1458.
Bennett C. Frank
Freier Susan M.
ISIS Patent Department
ISIS Pharmaceuticals Inc.
McGarry Sean
LandOfFree
Antisense modulation of CoREST expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense modulation of CoREST expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of CoREST expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3373253