Antisense modulation of cellular inhibitor of Apoptosis-2 expres

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

059587717

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-2. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-2 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-2 are provided.

REFERENCES:
Chu et al., Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control, Proc. Natl. Acad. Sci. U S A, 1997, 94:10057-10062.
Deveraux et al., IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases, Embo J., 1998, 17:2215-2223.
Rothe et al. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins, Cell, 1995, 83:1243-1252.
Rothe et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor, Cell, 1994, 78:681-692.
Roy et al., The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases, Embo J., 1997, 16:6914-6925.
Thompson, Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267:1456-1462.
Uren et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors, Proc. Natl. Acad. Sci. U S A, 1996, 93:4974-4978.
Wang et al., NF-kappaB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation, Science, 1998, 281:1680-1683.
Branch, TIBS 23 pp. 45-50, Feb. 1998.
Flanagan et al., Nature Biotech. 17:48-52, Jan. 1999.
Crooke, Antisense Research and Application, pp. 1-50, 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antisense modulation of cellular inhibitor of Apoptosis-2 expres does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense modulation of cellular inhibitor of Apoptosis-2 expres, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of cellular inhibitor of Apoptosis-2 expres will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-702480

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.