Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-12-03
1999-09-28
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585
Patent
active
059587717
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-2. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-2 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-2 are provided.
REFERENCES:
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Deveraux et al., IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases, Embo J., 1998, 17:2215-2223.
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Uren et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors, Proc. Natl. Acad. Sci. U S A, 1996, 93:4974-4978.
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Branch, TIBS 23 pp. 45-50, Feb. 1998.
Flanagan et al., Nature Biotech. 17:48-52, Jan. 1999.
Crooke, Antisense Research and Application, pp. 1-50, 1998.
Ackermann Elizabeth J.
Bennett C. Frank
Cowsert Lex M.
ISIS Pharmaceuticals Inc.
LeGuyader John L.
Schmidt Melissa
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