Antisense modulation of C-reactive protein expression

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S006120, C435S375000, C435S377000, C536S023100, C536S024100, C536S024500

Reexamination Certificate

active

06964950

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.

REFERENCES:
patent: 5582979 (1996-12-01), Weber
patent: 5783179 (1998-07-01), Nestor, Jr. et al.
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5998148 (1999-12-01), Bennett et al.
patent: 6764826 (2004-07-01), Yeh et al.
patent: 2002/0142283 (2002-10-01), Yeh et al.
patent: WO 96/06624 (1996-07-01), None
patent: WO99/00418 (1999-07-01), None
patent: WO 00/11207 (2000-02-01), None
Harold M. Weintraub, Scientific American, pp. 40-46.
Kuang-Yu Jen et al., Stem Cells, 2000; 18: pp. 307-319.
Andrea D. Branch, TIBS 23—Feb. 1998, pp. 45-50.
Sudhir Agrawal, TIBTECH, Oct. 1996, vol. 14, pp. 376-387.
Ridker et al., “Rapid Reduction in C-Reactive Protein with Cerivastatin Among 785 Patients with Primary Hypercholesterolemia”,Circulation2001 1191-1193.
Szalai et al., “C-Reactive Protein Structural Biology, Gene Expression, and Host Defense Function”,Immunologic Research1997 16/2:127-136.
Westhuyzen et al., “Review:Biology and Relevance of C-Reactive Protein in Cardiovascular and Renal Disease”,Annals of Clinical&Laboratory Science2000 30(2):133-143.
Yudkin et al., “Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?”,Atherosclerosis2000 148:209-214.
Ruuskanen et la., “C-reactive protein in respiratory virus infections”,J. Pediatrics1985 97-100.
Arici et al., “End-stage renal disease, atherosclerosis, and cardiovascular mortality: Is C-reactive protein the missing link?”,Kidney Intl.2001 59:407-414.
Bárány P., “Inflammation, serum C-reactive protein, and erythropoietin resistance”,Nephrol. Dial Transplant2001 16:224-227.
Gabay et al., “Acute-Phase Proteins and Other Systemic Responses to Inflammation”,New England J. Of Medicine1999 448-454.
Highton et al., “The Presence and Possible Significance of C-Reactive Protein in Rheumatoid Inflammation”,J. Rheumatology1985 871-875.
Hulthe et al., “Relationship between C-reactive protein and intima-media thickness in the cartoid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) Study”,Clinical Science2001 100:371-378.
Lagrand et al., “C-Reactive Protein as a Cardiovascular Risk Factor More Than an Epiphenomenon?”,CRP and Cardiovascular Disease1999 96:102.
Lei et al., “Genomic DNA Sequence for Human C-reactive Protein”,J. Biol. Chem.1985 260(24):13377-13383.
Morrow et al., “C-Reactive Protein, Inflammation, and Coronary Risk”,Med. Clinics of North America2000 84(1):149-161.
Ridker et al., “Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events”,N. Engl. J. Med.2001 344(6):1959-1965.
Bennett et al., “Antisense oligoncleotides as a tool for gene functionalization and target validation”,Biochim. Biophys. ActaDec. 10, 1999 1489(1):19-30.
Woo et al., “Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component”,J. Biol. Chem.Oct. 25, 1985 260(24):13384-13388.

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