Antisense modulation of Beta catenin expression

Details Antisense modulation of Beta catenin expression Antisense modulation of Beta catenin expression

1999-06-25

2000-05-23

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 911, 435366, 435 6, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

060665009

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Beta catenin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Beta catenin. Methods of using these compounds for modulation of Beta catenin expression and for treatment of diseases associated with expression of Beta catenin are provided.

REFERENCES:
Branch, TIBS 23 pp. 45-50, Feb. 1998.
Flanagan et al, Nature Biotech 17:48-52, Jan. 1999.
Crooke, Basic Principles of Antisense Therapeutics, Antisense Research and Application, pp. 1-50, 1998.
Uhlman et al, Chem Rev, vol. 90, No. 4, pp. 543-584, 1990.
James, W. Antiviral Chem & Chemo. 2(4) 191-214, 1991.
Candidus et al, Cancer Res. 56, pp. 49-52, Jan. 1996.
Robbins et al, J. Exp. Med, vol. 183, pp. 1185-1192, Mar. 1996.
Nollet et al, Genomics 32, pp. 413-424, 1996.
Haegel et al., Lack of beta-catenin affects mouse development at gastrulation, Development, 1995, 121:3529-3537.
Heasman et al., Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos, Cell, 1994, 79:791-803.
Ilyas et al., The interactions of APC, E-cadherin and beta-catenin in tumor development and progression, J. Pathol., 1997, 182:128-137.
Kim et al., Tissue-specific expression of beta-catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness, Exp. Cell. Res., 1998, 245:79-90.
Korinek et al., Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma, Science, 1997, 275:1784-17870
Morin et al., Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, 1997, 275:1787-1790.
Peifer, Cancer, catenins, and cuticle pattern: a complex connection, Science, 1993, 262:1667-1668.
Rubinfeld et al., Stabilization of beta-catenin by genetic defects in melanoma cell lines, Science, 1997, 275:1790-1792.
Willert et al., Beta-catenin: a key mediator of Wnt signaling, Curr. Opin. Genet. Dev., 1998, 8:95-102.

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