Antisense modulation of B7 protein expression

Details Antisense modulation of B7 protein expression Antisense modulation of B7 protein expression

2006-10-03

2006-10-03

Priebe, Scott D. (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C536S024500

Reexamination Certificate

active

07115580

ABSTRACT:
Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
patent: 5667998 (1997-09-01), Dougherty et al.
patent: 6077833 (2000-06-01), Bennett et al.
patent: 6319906 (2001-11-01), Bennett et al.
Gerwitz, A.M. et al., “Facilitating oligonucleotide delivery: Helping antisense deliver on its promise”, 1996, PNAS, vol. 93: pp. 3161-3163.
Gura, T., “Antisense has growing pains”, 1995, Science, vol. 270: pp. 575-577.
Alberts et al., “Molecular Biology of the Cell”, 1983, Garland Publishing Inc., New York, pp. 411-415.
Allison et al., “The Yin and Yang of T Cell Costimulation”,Science, 1995, 270, 932-933.
Allison, J.P, “CD28-B7 interactions in T-cell activation”,Curr. Opin. Immunol., 1994, 6, 414.
Azuma et al., “B70 antigen is a second ligand for CTLA-4 and CD28”,Nature, 1993, 366, 76-79.
Berkow et al., eds., “The Merck Manual of Diagnosis and Therapy”, 15th Ed., 1987, Rahway, N.J., pp. 302-336 and 2516-2522.
Borriello et al., Characterization of the Murine B7-1 Genomic Locus Reveals an Additional Exon Encoding an Alternative Cytoplasmic Domain and a Chromosomal.
Borriello et al., “Differential Expression of Alternate mB7-2 Transcripts”,J. Immunol., 1995, 155, 5490-5497.
Brigstock et al., “Species-Specific High Molecular Weight Forms of Basic Fibroblast Growth Factors”,Growth Factors, 1990, 4, 45-52.
Charachon et al., “Phosphorothioate Analogues of (2′-5′) (A)4: Agonist and Antagonist Activities in Intact Cells”,Biochemistry, 1990, 29, 2550-2555.
Chen et al., “Monoclonal Antibody 2D10 Recognizes a Novel T cell Costimulatory Molecule on Activated Murine B Lymphocytes”,J. Immunol., 1994, 152, 2105-2114.
Chen et al., “Molecular Cloning and Expression of Early T Cell Costimulatory Molecule-1 and its Characterization as B7-2 Molecule”,J. Immunol., 1994.
Crooke et al., eds., “Antisense Research and Applications”, CRC Press, Boca Raton, 1993, pp. 171-172.
Crooke et al., “Pharmokinetic Properties of Several Novel Oligonucleotide Analogs in mice”,J. Pharmacol. Exp. Ther., 1996, 277, 923-937.
DeVirgilio et al., Cloning and Disruption of a Gene Required for Growth on Acetate but not on Ethanol: the Acetyl-Coenzyme A Synthetase Gene ofSaccharomyces.
Dulbecco et al., “Plaque Production by the Polyoma Virus”,Virol., 1959, 8, 396-397.
Freeman et al., “Cloning of B7-2: A CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation”,Science, 1993, 262, 909-911.
Freeman et al., “B7, A New Member of the Ig Superfamily with Unique Expression on Activated and Neoplastic B Cells”,J. Immunol., 1989, 143, 2714-2722.
Freeman et al., “Structure, Expression, and T Cell Costimulatory Activity of the Murine Homologue of the Human B Lymphocyte Activation Antigen B7”,J. Exp.
French et al., “Express of Two Related Nonstructural Proteins of Bluetongue Virust (BTV) Type 10 in Insect Cells by a Recombinant Baculovirus: Production of Polyclonal Ascitic Fluid and Characterization of the Gene Product in BTV-Infected BHK Cells”, J.
Gebeyehu, G., et al., “Novel biotinylated nucleotide—analogs for labeling and colorimetric detection of DNA”,Nucleic Acids Res., 1987, 15, 4513-4534.
Gelbert et al., “Analysis of GPT Activity in Mammalian Cells with a Chromosomally Integrated Shuttle Vector Containing Altered gpt Genes”,Somat. Cell. Mol.
Gold and Stormo, in:Escherichia coliandSalmonella typhimurium: Cellular and Molecular Biology, vol. 2, 1987.
Hakim et al., “Acute Graft-Versus-Host Reaction Can be Aborted by Blockade of Costimulatory Molecules”,J. Immun., 1995, 155, 1760-1766.
Harlan et al., “Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness”,Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 3137.
Hathcock et al., “Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation”,Science, 1993, 262, 905-907.
Inobe et al., “The Role of the B7-1a Molecule, an Alternatively Spliced Form of Murine B7-1 (CD80), on T Cell Activation”,J. Immun., 1996, 157, 582-588.
Jellis et al., “Genomic Organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)”,Immunogenet., 1995, 42, 85.
June et al., “The B7 and CD28 receptor families”,Immunol. Today, 1994, 15, 321-331.
Kabanov et al., A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and.
Kanagasundaram et al., “Isolation and characterization of the gene encoding gluconolactonase fromZymomonas mobilis”, Biochim. Biophys. Acta, 1992, 1171, 198-200.
Kornberg, A., DNA Replication, 1974, W.H. Freeman & Co., San Francisco, 1974, pp. 75-77.
Lenschow et al., “Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4Ig”, 1992,Science, 257, 789-792.
Lenschow et al.,Curr. Opin. Immunol., 1993, 5(5), 747-52.
Lenschow et al., “Expression and functional significance of an additional ligand for CTLA-4”,Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 11054-11058.
Letsinger et al., Cholesteryl-conjugated oligonucleotides: Synthesis, properties, and activity as inhibitors or replication of human immunodeficiency.
Levine et al., “Antiviral Effect and Ex Vivo CD4+T Cell Proliferation in HIV-Positive Patients as a Result of CD28 Costimulation”,Science, 1996, 272, 1939-1942.
Lin et al., “Long-Term Acceptance of Major Histocompatibility Complex Mismatched Cardiac Allografts Induced by CTLA4Ig Plus Donor-specific Transfusion”,J.
Linsley et al., “CTLA-4 Is a Second Receptor for the B Cell Activation Antigen B7”,J. Exp. Med., 1991, 174, 561-569.
Linsley et al., “Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule”,Science, 1992, 257, 792-795.
Linsley and Ledbetter, “The Role of the CD28 Receptor During T Cell Responses to Antigen”,Annu. Rev. Immunol., 1993, 11, 191-212.
Liu and Linsley, “Costimulation of T-cell growth”,Curr. Opin. Immunol., 1992, 4, 265-270.
Manoharan et al., “Cholic Acid-Oligonucleotide Conjugates for Antisense Applications”,Bioorg. Med. Chem. Let., 1994, 4, 1053-1060.
Manoharan et al., “Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents”,Nucleosides&Nucleotides, 1995, 14.
Manoharan et al., “Chemical Modifications to Improve Uptake and Bioavailability of Antisense Oligonucleotides”,Ann. N.Y. Acad. Sci., 1992, 660, 306.
Manoharan et al., “Lipidic Nucleic Acids”,Tetrahedron Lett., 1995, 36, 3651-3654.
Manoharan et al., Introduction of a Lipophilic Thioether Tether in the Minor Groove of Nucleic Acids for Antisense Applications:,Bioorg. Med. Chem. Let.
Markussen et al., “Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly”,Development, 1995, 121, 3723-3732.
Martin et al., “Ein neuer Zugang zu 2′-O-Alkyribonucleosiden und Eigenschaften deren Oligonucleotide”,Helv. Chim. Acta, 1995, 78, 486-504.
McDermott et al., “Stucture and lens expression of the gene encoding chicken βA3/A1-crystallin”,Gene, 1992, 117, 193.
Mishra et al., “Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery”,Biochi

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