Antisense microRNA and uses therefor

Details Antisense microRNA and uses therefor Antisense microRNA and uses therefor

2008-08-01

2010-10-12

Bowman, Amy (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024300, C536S024330, C536S024500

Reexamination Certificate

active

07812003

ABSTRACT:
Provided herein are methods to suppress specificity protein (Sp) activity in a cell associated with a cell proliferative disease. The methods are effective to inhibit a microRNA in the cell using an antisense microRNA oligonucleotide which results in an increase in expression of a specificity protein (Sp) suppressor gene thereby inducing Sp degradation, apoptosis or growth arrest by releasing inhibitors of G2/M (Myt-1) or inhibition. Also provided are methods of treating a cancer using the antisense microRNA oligonucleotide. In addition the present invention provides antisense microRNA-27a oligonucleotides useful in the methods described herein.

REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 2008/0050744 (2008-02-01), Brown et al.
Scott et al., Rapid Alteration of MicroRNA Levels by Histone Deacetylase Inhibition, 2006, Cancer Res, 66(3), pp. 1277-1281.

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