Antisense inhibitors of the human immunodeficiency virus phospho

Details Antisense inhibitors of the human immunodeficiency virus phospho Antisense inhibitors of the human immunodeficiency virus phospho

1990-05-11

1992-11-24

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 27, 536 28, 536 29, A61K 3170

Patent

active

051661950

ABSTRACT:
Methods for modulating the expression of the HIV tat gene are disclosed comprising contacting tat RNA with oligonucleotide or oligonucleotide analog which can bind with at least a portions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to portions of the tat RNA which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are disclosed.

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