Antisense inhibition of TNFR1 expression

Details Antisense inhibition of TNFR1 expression Antisense inhibition of TNFR1 expression

1998-06-26

1999-12-28

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435325, 435366, 435377, 536 231, 536 2431, 536 245, C07H 2104, C12Q 168, C12N 1585, C12N 1511

Patent

active

060079959

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of TNFR1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TNFR1. Methods of using these compounds for modulation of TNFR1 expression and for treatment of diseases associated with expression of TNFR1 are provided.

REFERENCES:
patent: 5789573 (1998-08-01), Baker et al.
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Gewirtz et al., Facilitating oligonucleotide delivery: helping antisense deliver on its promise, Proc. Natl. Acad. Sci., vol. 93, pp. 3161-3163, Apr. 1996.
Branch, A good antisense molecule is hard to find, TIBS, vol. 23, pp. 45-50, Feb. 1998.
Crooke et al., Basic Principles of Antisense Therapeutics, Antisense Research and Application, pp. 1-50, Jul. 7, 1998.
Akhtar et al., Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes), Nucleic Acids Research, vol. 19 (20), pp. 5551-5559, 1991.
Shen et al., Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotide increase hypoxic injury and B-amyloid toxicity in human neuronal cell line, J. Biol. Chem., Feb. 1997.
Lotz et al., The nerve growth factor /tumor necrosis factor receptor family, J. Leukoc. Biol., 1996, 60:1-7.
Ojwang et al., Modified Antisense Oligonucleotides Directed against Tumor Necrosis Factor Receptor Type I Inhibit Tumor Necrosis Factor a-Mediated Functions, Biochemistry, 1997, 36:6033-6045.
Tracey et al., Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Ann. Rev. Med., 1994, 45:491-503.

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