Antisense inhibition of SRC-3 expression

Details Antisense inhibition of SRC-3 expression Antisense inhibition of SRC-3 expression

1999-11-15

2000-12-05

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435325, 536 245, 536 231, 536 243, 536 2431, 536 2433, C12N 1585, C07H 2104, C12Q 168

Patent

active

061565717

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of SRC-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SRC-3. Methods of using these compounds for modulation of SRC-3 expression and for treatment of diseases associated with expression of SRC-3 are provided.

REFERENCES:
Carey et al. Biochemical and Biophysical Research Communications, 249 (1), p. 283-286, Aug. 1998.
Anzick et al., AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer, Science, 1997, 277:965-968.
Chen et al., Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300, Cell, 1997, 90:569-580.
Li et al., The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation, J. Biol. Chem., 1998, 273:5948-5954.
Li et al., RAC3, a steroid
uclear receptor-associated coactivator that is related to SRC-1 and TIF2, Proc. Natl. Acad. Sci. U. S. A., 1997, 94:8479-8484.
Torchia et al., The transcriptional do-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments], Nature, 1997, 387:677-684.

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