Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-02-23
2000-03-21
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435325, 435366, 435455, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500
Patent
active
060401788
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Smad5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad5. Methods of using these compounds for modulation of Smad5 expression and for treatment of diseases associated with expression of Smad5 are provided.
REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
Bruno et al. Blood 91: 1917-1923, 1998 (Mar. 15).
Milner et al. Nature Biotechnology 15:537-541 Jun. 1997.
James et al. Antiviral Chem. & Chemotherapy 1991:2(4):191-214.
Heldin et al., TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, 1997, 390:465-471.
Kretzschmar et al., SMADs: mediators and regulators of TGF-beta signaling, Curr. Opin. Genet. Dev., 1998, 8:103-111.
Nishimura et al., Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12, J. Biol. Chem., 1998, 273:1872-1879.
Wrana, TGF-beta receptors and signalling mechanisms, Miner. Electrolyte Metab., 1998, 24:120-130.
Yamamoto et al., Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts, Biochem. Biophys. Res. Commun., 1997, 238:574-580.
Milner et al. Nature Biotechnology 15:537-541, Jun. 1997.
Crooke, S.T. Ch1, "Antisense Research & Application" Springer, pp. 1-50, 1998.
Branch TIBS 23:45-50 Feb. 1998.
Cowsert Lex M.
Monia Brett P.
Isis Pharmaceuticals , Inc.
LeGuyader John L.
LandOfFree
Antisense inhibition of Smad5 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense inhibition of Smad5 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense inhibition of Smad5 expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-729763