Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-04-30
1999-10-12
Fredman, Jeffrey
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 245, 536 2721, 536 284, 536 285, 435 6, 514 44, C07H 2102, C07H 2104, C12Q 168, A61K 4800
Patent
active
059657227
ABSTRACT:
Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provide that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
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Cook Phillip Dan
Ecker David J.
Freier Susan M.
Monia Brett P.
Sanghvi Yogesh S.
Fredman Jeffrey
ISIS Pharmaceuticals Inc.
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