Antisense inhibition of PI3K p85 expression

Details Antisense inhibition of PI3K p85 expression Antisense inhibition of PI3K p85 expression

1999-06-25

2000-08-08

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

536 245, 536 231, 514 44, 435 6, 435 911, 435455, C07H 2102, C07H 2104, C12Q 168, C12P 1934, A01N 4304

Patent

active

061000906

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of PI3K p85. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3K p85. Methods of using these compounds for modulation of PI3K p85 expression and for treatment of diseases associated with expression of PI3K p85 are provided.

REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
Bhargavi et al., Phosphatidylinositol 3-kinase binds to profilin through the p85 alpha subunit and regulates cytoskeletal assembly [In Process Citation], Biochem. Mol. Biol. Int., 1998, 46:241-248.
Chen et al., Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase, Proc. Natl. Acad. Sci. U. S. A., 1994, 91:10148-10152.
Escobedo et al., cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor, Cell, 1991, 65:75-82.
Fry, Structure, regulation and function of phosphoinositide 3-kinases, Biochim. Biophys. Acta., 1994, 1226:237-268.
He et al., Association of the p85 regulatory subunit of phosphatidylinositol 3- kinase with an essential erythropoietin receptor subdomain, Blood, 1993, 82:3530-3538.
Jimenez et al., Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase, Embo J., 1998, 17:743-753.
Kontos et al., Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt, Mol. Cell. Biol., 1998, 18:4131-4140.
Otsu et al., Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase, Cell, 1991, 65:91-104.
Skolnik et al., Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases, Cell, 1991, 65:83-90.
Ui et al., Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase, Trends Biochem. Sci., 1995, 20:303-307.
Vlahos et al., A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), J. Biol. Chem., 1994, 269:5241-5248.
Woscholski et al., A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase, FEBS Lett., 1994, 342:109-114.
Skorski et al, Blood 86 (2), 726-736 (1995).
Zauli, et al, Blood 89(3), 883-895(1997).
Shigematsu, et al, J. Biol Chem., 272(22), 14334-14340 (1997).
Crooke, et al, "Antisense Research & Applications" Chapter 1, CRC Press.
Milner et al, Nature Biotechnology, 15, 537-541 (1997).
James, W, Antiviral Chem. & Chemo., 2 (4), 191-214 (1991).
Sanghvi, YS., "Heterocyclic Base Modifications in Nucleic Acids & Their Application in Antisense Oligo's", 273-288(1993).

Affiliated with

Also associated with

Rating

Antisense inhibition of PI3K p85 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense inhibition of PI3K p85 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense inhibition of PI3K p85 expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1149195