Antisense inhibition of PEPCK-mitochondrial expression

Details Antisense inhibition of PEPCK-mitochondrial expression Antisense inhibition of PEPCK-mitochondrial expression

1999-08-03

2000-02-29

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C07H 2104, C12M 1500

Patent

active

060308370

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of PEPCK-mitochondrial. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PEPCK-mitochondrial. Methods of using these compounds for modulation of PEPCK-mitochondrial expression and for treatment of diseases associated with expression of PEPCK-mitochondrial are provided.

REFERENCES:
Hanson et al., Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme, Adv. Enzymol. Relat. Areas Mol. Biol., 1994, 69:203-281.
Modaressi et al., Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression, Biochem. J., 1998, 333:359-366.
Modaressi et al., Molecular cloning, sequencing and expression of the cDNA of the mitochondrial form of phosphoenolpyruvate carboxykinase from human liver, Biochem. J., 1996, 315:807-814.
Stoffel et al., cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band 2q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young, Hum. Mol. Genet., 1993, 2:1-4.

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