Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-10-27
2000-10-24
Elliott, George C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C07H 2104, C12N 1500
Patent
active
061366048
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of methionine aminopeptidase 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding methionine aminopeptidase 2. Methods of using these compounds for modulation of methionine aminopeptidase 2 expression and for treatment of diseases associated with expression of methionine aminopeptidase 2 are provided.
REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5885820 (1999-03-01), Chang
patent: 5888796 (1999-03-01), Chang
Agrawal, TIBTech, vol. 14, p. 376-387, Oct. 1996.
Branch, TIBS23, p. 45-50, Feb. 1998.
James, Antiviral Chemistry and Chemotherapy, 2(4), p. 191-214, 1991.
Milner et al., Nature Biotechnology, vol. 15, p. 537-541, Jun. 1997.
Crooke, "Antisense Research and Application"; Springer, New York; p. 1-50, Oct. 1996.
Arfin et al., Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes, Proc. Natl. Acad. Sci. U. S. A., 1995, 92:7714-7718.
Bose et al., Viral infection. I. Regulation of protein synthesis during vaccinia viral infection of animal cells, Arch. Biochem. Biophys., 1997, 342:362-372.
Chakraborty et al., Regulation of eIF-2 alpha-subunit phosphorylation in reticulocyte lysate, Biochemistry, 1994, 33:6700-6706.
Chatterjee et al., Expression and activity of p67 ae induced during heat shock, Biochem. Biophys. Res. Commun., 1998, 249:113-117.
Datta et al., Induction of apoptosis due to lowering the level of eukaryotic initiation factor 2-associated protein, p67, from mammalian cells by antisense approach, Exp. Cell. Res., 1999, 246:376-383.
Datta et al., Increased Phosphorylation of Eukaryotic Initiation Factor 2alpha at the G2/M Boundary in Human Osteosarcoma Cells Correlates with Deglycosylation of p67 and Decreased Rate of Protein Synthesis, Exp. Cell. Res., 1999, 250:223-230.
Data et al., Glycosylation of eukaryotic peptide chain initiation factor 2 (eIF-2)- associated 67-kDa polypeptide (p67) and its possible role in the inhibition of eIF-3 kinase-catalyzed phophorylation of the eIF-2 alpha-subunit, J. Biol. Chem., 1989, 264:20620-20624.
Griffith et al., Molecular recognition of angiogenesis inhibitor fumagillin and ovalicin by methionine aminopeptidease 2, Proc. Natl. Acad. Sci. U. S. A., 1998, 95:15183-15188.
Griffith et al., Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin, Chem. Biol., 1997, 4:461-471.
Gupta et al., p67 transcription regulates translation in serum-starved and mitogen- activated KRC-7 cells, J. Biol. Chem., 1997, 272:12699-12704.
Gupta et al., Regulation of an eukaryotic initiation factor-2 (eIF-2) associated 67 kDa glycoprotein (p67) and its requirement in protein synthesis, Gene Expr., 1995, 5:113-122.
Li et al., Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67), Biochim. Biophys. Acta., 1995, 1260:333-336.
Li et al., Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase, Biochem. Biophys. Res. Commun., 1996, 227:152-159.
Ray et al., Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide, Biochemistry, 1993, 32:5151-5159.
Saha et al., Viral infection. II. Hemin induces overexpression of p67 as it partially prevents appearance of an active p67-deglycosylase in baculovirus-infected insect cells, Arch. Biochem. Biophys., 1997, 342:373-382.
Turk et al., Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression, Bioorg. Med. Chem., 1998, 6:1163-1169.
Monia Brett P.
Wyatt Jacqueline
Elliott George C.
Isis Pharmaceuticals , Inc.
Lacourciere Karen A
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