Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-11-25
1999-11-16
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585
Patent
active
059856637
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin-15. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin-15. Methods of using these compounds for modulation of Interleukin-15 expression and for treatment of diseases associated with expression of Interleukin-15 are provided.
REFERENCES:
patent: 5795966 (1998-08-01), Grabstein et al.
Branch, TIBS 23, pp. 45-50, Feb. 1998.
Flanagan et al, Nature Biotech. 17: 48-52, Jan. 1999.
Crooke, Basic Principles of Antisense Therapeutics, from Antisense Research & Application, pp. 1-50, 1998.
Agostini et al., Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis, J. Immunol., 1996, 157:910-918.
Bamford et al., Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation, Proc. Natl. Acad. Sci. U S A, 1996, 93:2897-2902.
Barzegar et al., IL-15 is produced by a subset of human melanomas, and is involved in the regulation of markers of melanoma progression through juxtacrine loops, Oncogene, 1998, 16:2503-2512.
Burton et al., A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells, Proc. Natl. Acad. Sci. U S A, 1994, 91:4935-4939.
Carson et al., Interleukin-15 as a potential regulator of the innate immune response, Braz. J. Med. Biol. Res., 1998, 31:1-9.
Grabstein et al., Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor, Science, 1994, 264:965-968.
Guex-Crosier et al., Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases, J. Immunol., 1997, 158:452-458.
Kim et al., Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity, J. Immunol., 1998, 160:5742-5748.
Kirman et al., Interleukin-15 and its role in chronic inflammatory diseases [In Process Citation], Inflamm. Res., 1998, 47:285-289.
Kivisakk et al., IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS), Clin. Exp. Immunol., 1998, 111:193-197.
Kumaki et al., Prolonged secretion of IL-15 in patients with severe forms of acute graft-versus-host disease after allogeneic bone marrow transplantation in children, Int. J. Hematol., 1998, 67:307-312.
Loubeau et al., Enhancement of natural killer and antibody-dependent cytolytic activities of the peripheral blood mononuclear cells of HIV-infected patients by recombinant IL-15, J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 1997, 16:137-145.
McInnes et al., Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis, Immunol. Today, 1998, 19:75-79.
Meazza et al., Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines, Oncogene, 1996, 12:2187-2192.
Pilson et al., Bispecific humanized anti-IL-2 receptor alpha beta antibodies inhibitory for both IL-2-and IL-15-mediated proliferation, J. Immunol., 1997, 159:1543-1556.
Tagaya et al., IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels, Immunity, 1996, 4:329-336.
Tagaya et al., Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells, Embo J., 1996, 15:4928-4939.
Yamada et al., Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells, Blood, 1998, 91:4265-4272.
Bennett C. Frank
Cowsert Lex M.
Isis Pharmaceuticals , Inc.
LeGuyader John L.
Schmidt Melissa
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