Antisense inhibition of integrin .alpha.4 expression

Details Antisense inhibition of integrin .alpha.4 expression Antisense inhibition of integrin .alpha.4 expression

1998-10-05

1999-10-19

LeGuyader, John

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500

Patent

active

059688262

ABSTRACT:
Compositions and methods are provided for modulating the expression of integrin .alpha.4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin .alpha.4 are preferred. Methods of using these compounds for modulating integrin .alpha.4 expression and for treatment of diseases associated with expression of integrin .alpha.4 are also provided.

REFERENCES:
Lallier and Bronner-Fraser, "Inhibition of Neural Crest cell Attachment by Interin Antisense Oligonucleotides", Science, 1993, 259:692-695.
Kil, et al., "Inhibition of Cranial Neural Crest Adhesion in Vitro and Migration in Vivo Using Integrin Antisense Oligonucleotides", 1996, Devel. Biol. 179:91-101.
Breach TI BS 23:45-50, Feb. 1998.
Crooke, Ch 1 of Antisense Res. & Applications, Springer, 1998, pp. 1-50.

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