Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2

Details Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2

1996-05-24

1998-08-04

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 536 2433, 435 6, 435 911, C07H 2102, C07H 2104, C12Q 168

Patent

active

057895732

ABSTRACT:
Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably said oligomers inhibit protein translation directly via interference with ribosome assembly.

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